100,000,000,000

EXOSOME

高濃度エクソソーム
点鼻療法ネブライザー療法

Wharton Jerry Umbilical Cord
Stem cell supernatant containing high-concentration exosomes

Guaranteed to contain 100 billion exosomes per vial (2cc)

More than 10 times the concentration of exosomes made by other companies!
Guaranteed to contain over 100 billion!

今すぐ購入する

点鼻、ネブライザー療法の優位姓

血液脳関門を突破する治療法

With normal infusion, the active ingredients in the culture supernatant cannot pass through the blood-brain barrier (BBB) in the capillaries in the brain.

脳疾患をはじめ、中枢神経系疾患の治療、特に認知症予防及び初期段階の治療において極めて効果的

What is the blood-brain barrier (BBB)?

The BBB is a barrier that strictly limits the movement of substances from the blood to the brain in order to protect the brain. The brain is a very delicate organ and needs to be protected from harmful substances. Therefore, many substances cannot pass through the BBB.

Exosomes are very small nano-sized particles with a lipid bilayer structure that allows them to pass through the blood-brain barrier (BBB) smoothly. This is related to the fact that the size and structure of exosomes are suitable for the gaps in the BBB and the affinity with cell membranes, and that the receptors on their surface interact with receptors on BBB cells and are actively taken up. On the other hand, growth factors and cytokines have large molecular weights and do not have a lipid bilayer membrane, making it difficult for them to pass through the BBB, and their effect on the brain is limited. The ability of exosomes to pass through the BBB offers new possibilities in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, brain tumors, and brain injuries, and is attracting attention as a groundbreaking medical technology that enables a direct approach to the brain that was not reachable by conventional treatments. At our hospital, we offer a new option to support the health of our patients through this cutting-edge exosome therapy.

Uses intranasal administration that crosses the BBB (blood-brain barrier)

This method is expected to deliver exosomes directly into the brain, improving the effectiveness of treatment for neurological diseases. Exosomes are thought to promote the regeneration of nerve cells and repair neural circuits. If you are suffering from a neurological disease such as cerebral infarction, please feel free to contact us.

Highly concentrated exosomes

点鼻療法

Efficiently bypasses the blood-brain barrier
Repair damaged brain cells!

Our nasal drop treatment involves using a spray device to inject concentrated exosomes into the nasal cavity.
With regular infusions, the active ingredients in exosome concentrates often cannot pass through the blood-brain barrier in the capillaries in the brain.
Therefore, treatment with nasal drops rather than intravenous drips can improve brain diseases and functional decline caused by aging.
After consultation with a doctor, patients can easily administer the drug at home.

Highly concentrated exosomes

Nebulizer therapy

Inhalation therapy using a nebulizer is effective for treating the lungs and brain. In this method, the functional components of stem cell culture supernatant travel from the nasal cavity and oral cavity through the pharynx to the bronchi and alveoli, and then adhere to the nasal mucosa to act on the area of olfactory disorder, and some even reach the brain. This is expected to directly affect the cranial nervous system, pharynx, and respiratory system, repairing and improving symptoms of the cranial nervous system such as memory disorders, sleep disorders, decreased concentration, anxiety/depression, and chronic inflammation, as well as symptoms of the pharynx and respiratory system such as coughing, phlegm, olfactory disorders, taste disorders, shortness of breath, bronchial inflammation, decreased lung capacity, and emphysema.

点鼻療法とネブライザー療法の選び方

最新の研究では、特に神経系疾患の治療において点鼻療法やネブライザー療法の効果を検証しています。

例えば、アルツハイマー病やパーキンソン病などの神経変性疾患、脳梗塞の後遺症、さらには特定の認知機能障害に対する治療法として、中枢神経系疾患、特に頚椎症、頚椎ヘルニア、腰椎椎間板ヘルニア、頸椎脊柱管狭窄症などの治療として、点鼻療法やネブライザー療法が検討されています。

点鼻療法

毎日投与が必要ですが、脳への到達効率が点滴比で3倍高いといわれており、神経保護効果の持続性が優れるとされます。認知機能改善や脳疲労回復に最適。

ネブライザー療法

肺からの吸収を利用し、血流を介して全身にエクソソームを届ける方法。特に呼吸器系の疾患や全身の炎症改善に優れ、点滴と点鼻の中間的な役割を果たします。

目的に応じた組み合わせが理想的！

全身の抗炎症作用を狙うなら「点滴」ですが、脳機能回復を重視するなら「点鼻」、呼吸器系の疾患や即効性を求めるなら「ネブライザー」がおすすめです。

点鼻療法/ネブライザー療法の効果効能

1. 直接アプローチで即効性が期待できる

鼻や肺の粘膜から直接吸収され、全身へと素早く行き渡ります。

※ノルウェーのベルゲン大学との共同臨床研究（2019年開始）では、アルツハイマー患者の認知機能スコア（MMSE）が6ヶ月間の継続投与で平均15%向上したとされています。（詳細なデータは非公開）

2. 炎症を抑え、免疫バランスを整える

エクソソームは、炎症性サイトカインを抑制し、抗炎症性サイトカインを増加させる作用があります。点鼻・ネブライザー療法では、エクソソームが鼻腔や肺の粘膜から吸収され、全身に運ばれることで、アレルギー症状の緩和や、自己免疫疾患の症状軽減が期待されます。花粉症やアトピー性皮膚炎などの患者様において、症状の緩和やQOLの向上が期待されています。

※3ヶ月の継続使用でアレルギー性鼻炎の症状が70%軽減されるという、導入クリニックの症例集積。

3. 神経細胞を修復し、脳の若返りをサポート

エクソソームが脳の神経細胞を活性化し、修復を促進します。

脳疲労の改善や、認知機能低下の予防・回復が期待できます。

※6ヶ月の使用で、脳梗塞後遺症の回復スピードが従来のリハビリ療法比で1.5倍向上したとする予備的なデータがあります。（非公開臨床試験）

4. 呼吸器機能の改善〜肺組織の修復と炎症抑制〜

ネブライザー療法では、エクソソームが肺組織に直接働きかけ、損傷した細胞の修復や炎症の抑制を促します。これにより、呼吸機能の改善、慢性的な呼吸器疾患の症状緩和、肺の健康維持が期待できます。喘息や慢性閉塞性肺疾患（COPD）などの患者様において、呼吸困難の軽減やQOL（生活の質）の向上が期待されます。

5. 持続性と安全性〜継続的なケアで効果を実感〜

エクソソーム点鼻・ネブライザー療法は、継続的なケアにより、効果を最大限に実感いただけます。特に最初の数回は、一定期間ごとに治療を行い、細胞の修復や再生を集中的にサポートすることが推奨されます。その後は、効果を見ながら治療頻度を調整し、メンテナンスとして継続することで、長期的な効果が期待できます。安全性に関しては、専門医の指導のもと、適切な投与量と方法で治療を行うことで、重篤な副作用のリスクは極めて低いと考えられています。

エクソソーム点鼻・ネブライザー療法は、あなたの健康の可能性を拡げます。

最先端の再生医療技術を応用し、あなたの健康と美を内側からサポートする革新的な治療法です。専門医による丁寧なカウンセリングと適切な治療計画により、あなたの理想とする健康と美の実現をサポートします。

エクソソーム個数

Characteristics of our stem cell supernatant

100 billion pieces/2cc

100,000,000,000

EXOSOME

The stem cell-containing semen containing high concentrations of exosomes that we use at our clinic is

It contains an overwhelming amount of active ingredients (approximately 10 times) compared to previous exosome treatments.

Conventional products that are said to have high concentrations of exosomes are

The amount of exosomes contained in 1 cc is approximately 5 billion.

In comparison, the high-concentration exosome-containing stem cell semen we handle at our clinic is

We guarantee that 1cc contains approximately 10 times the content, or 50 billion particles .

*Exosome content is based on detection data from a third-party organization

In addition, it contains a rich amount of more than 500 types of growth factors and cytokines.

"EGF" epidermal growth factor (promotes cell turnover, improves dark spots and dullness)

"VEGF" Vascular endothelial growth factor (hair growth and hair restoration)

"HGF" Hepatocyte growth factor (tissue regeneration)

In particular, the above three types of growth factors are contained in a high concentration of 6000pg/ml on average , so many effects can be expected. In addition, the above three types of growth factors are guaranteed to contain 1000pg/ml.

*Growth factor content is based on detection data from a third-party organization

Safety of exosome infusion at our hospital

When discussing the safety of stem cell supernatant products, the most important factor is the quality of the "culture medium."

The products we handle at our clinic not only contain high concentrations of exosomes, but are also extremely safe.

Even AOF medium, which is said to be one of the highest quality in Japan, has the problem of having to add heavy metals such as selenium compounds.

In contrast, the stem cell supernatant used at our clinic is a completely original SCS medium, which is a unique product that boasts unparalleled safety as it has succeeded in completely eliminating all heavy metals as well as hazardous substances such as toxic substances classified under the GHS.

The quality of exosomes depends heavily on the donor. One of the major features of Frontier's products is that they use only the highest quality donor cells.

At our clinic, we always put the safety of our customers first and foremost in our treatments.